Repeat Pregnancy Loss
Two or more miscarriages is defined as Repeat Pregnancy Loss. A large number of miscarriages are unexplained while a number of miscarriages are due to a chromosome or genetic disorder, uterine abnormality, or medical condition.
Chromosome abnormality is more common as the woman is older at the time of conception. The embryo receives a copy of chromosomes from the egg and a copy from the sperm. When the embryo does not get the correct number of chromosomes this can lead to miscarriage. As a female ages, the egg quality declines with a higher number of eggs being abnormal. Technology advances in invitro fertilization now offers testing on embryos by performing a biopsy on the developing embryo and sending the biopsied cells for testing called Preimplantation Genetic Screening, PGS.
Abnormalities within the uterus may also cause miscarriages. This may include uterine septum, polyp, or fibroid. These conditions can be diagnosed by performing a sonohysterogram, hysterosalpingogram, or ultrasound. If an abnormality is present, surgery can be performed to remove the septum, polyp, or fibroid.
A medical condition known as Antiphosolipid Syndrome can lead to miscarriage as well. Antiphospholipid antibodies are present and affect blood clotting. APA is tested with blood tests. If APA is detected, blood thinner such as Lovenox, is prescribed with subsequent pregnancies to thin the blood and reduce the risk of miscarriage.
Other tests include screening for thyroid and celiac disease.
If you have experienced repeat pregnancy loss and would like to explore your circumstances or further options to conceive, please call our office to schedule a consultation.